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1

Protein kinase affinity reagents based on a 5-aminoindazole scaffold

Ratika Krishnamurty, Amanda M. Brock, Dustin J. Maly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 475 KB

english, 2011

2

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics

Rose, John C, Stephany, Jason J, Valente, William J, Trevillian, Bridget M, Dang, Ha V, Bielas, Jason H, Maly, Dustin J, Fowler, Douglas M

Journal:

Year:

2017

Language:

english

File:

PDF, 657 KB

english, 2017

3

Kinome chemoproteomics characterization of pyrrolo[3,4- c ]pyrazoles as potent and selective inhibitors of glycogen synthase kinase 3

Golkowski, Martin, Perera, Gayani K., Vidadala, Venkata Narayana, Ojo, Kayode K., Van Voorhis, Wesley C., Maly, Dustin J., Ong, Shao-En

Journal:

Molecular Omics

Year:

2018

Language:

english

File:

PDF, 3.47 MB

english, 2018

4

Combinatorial Strategies for Targeting Protein Families: Application to the Proteases

Dustin J. Maly, Lily Huang, Jonathan A. Ellman

Journal:

Year:

2002

Language:

english

File:

PDF, 681 KB

english, 2002

5

ChemInform Abstract: Combinatorial Strategies for Targeting Protein Families: Application to the Proteases

Dustin J. Maly, Lily Huang, Jonathan A. Ellman

Journal:

Year:

2002

File:

PDF, 24 KB

2002

6

Affinity Reagents that Target a Specific Inactive Form of Protein Kinases

Pratistha Ranjitkar, Amanda M. Brock, Dustin J. Maly

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 834 KB

english, 2010

7

Reactive Landing of Gas-Phase Ions as a Tool for the Fabrication of Metal Oxide Surfaces for In Situ Phosphopeptide Enrichment

Grady R. Blacken, Michael Volný, Matthew Diener, Karl E. Jackson, Pratistha Ranjitkar, Dustin J. Maly, František Tureček

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2009

Language:

english

File:

PDF, 1.35 MB

english, 2009

8

Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-Guided ligand assembly

John W. Kehoe, Dustin J. Maly, Dawn E. Verdugo, Joshua I. Armstrong, Brian N. Cook, Ying-Bin Ouyang, Kevin L. Moore, Jonathan A. Ellman, Carolyn R. Bertozzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

9

Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays

Dhaval N. Gosalia, Cleo M. Salisbury, Dustin J. Maly, Jonathan A. Ellman, Scott L. Diamond

Journal:

Year:

2005

Language:

english

File:

PDF, 326 KB

english, 2005

10

Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL

Inna Goreshnik, Amanda M. Brock, Dustin J. Maly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 942 KB

english, 2011

11

Affinity-Based Probes Based on Type II Kinase Inhibitors

Ranjitkar, Pratistha, Perera, B. Gayani K., Swaney, Daniel L., Hari, Sanjay B., Larson, Eric T., Krishnamurty, Ratika, Merritt, Ethan A., Villén, Judit, Maly, Dustin J.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 6.66 MB

english, 2012

12

Active site profiling reveals coupling between domains in SRC-family kinases

Krishnamurty, Ratika, Brigham, Jennifer L, Leonard, Stephen E, Ranjitkar, Pratistha, Larson, Eric T, Dale, Edward J, Merritt, Ethan A, Maly, Dustin J

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 940 KB

english, 2012

13

Label Transfer Reagents to Probe p38 MAPK Binding Partners

Andrews, Simeon S., Hill, Zachary B., Perera, B. Gayani K., Maly, Dustin J.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.37 MB

english, 2013

14

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

Ojo, Kayode K, Larson, Eric T, Keyloun, Katelyn R, Castaneda, Lisa J, DeRocher, Amy E, Inampudi, Krishna K, Kim, Jessica E, Arakaki, Tracy L, Murphy, Ryan C, Zhang, Li, Napuli, Alberto J, Maly, Dustin

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 631 KB

english, 2010

15

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

Brigham, Jennifer L., Perera, B. Gayani K., Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.77 MB

english, 2013

16

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Wang, Likun, Perera, B Gayani K, Hari, Sanjay B, Bhhatarai, Barun, Backes, Bradley J, Seeliger, Markus A, Schürer, Stephan C, Oakes, Scott A, Papa, Feroz R, Maly, Dustin J

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 7.63 MB

english, 2012

17

A Mechanism-Based Cross-Linker for the Identification of Kinase−Substrate Pairs

Maly, Dustin J., Allen, Jasmina A., Shokat, Kevan M.

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

18

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

Statsuk, Alexander V., Maly, Dustin J., Seeliger, Markus A., Fabian, Miles A., Biggs, William H., Lockhart, David J., Zarrinkar, Patrick P., Kuriyan, John, Shokat, Kevan M.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 1.05 MB

english, 2008

19

Peptide Microarrays for the Determination of Protease Substrate Specificity

Salisbury, Cleo M., Maly, Dustin J., Ellman, Jonathan A.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 85 KB

english, 2002

20

Sequence Determinants of a Specific Inactive Protein Kinase Conformation

Hari, Sanjay B., Merritt, Ethan A., Maly, Dustin J.

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

21

Probing Low Affinity and Multivalent Interactions with Surface Plasmon Resonance: Ligands for Concanavalin A

Mann, David A., Kanai, Motomu, Maly, Dustin J., Kiessling, Laura L.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 225 KB

english, 1998

22

Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors

Krishnamurty, Ratika, Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2010

Language:

english

File:

PDF, 3.43 MB

english, 2010

23

Design, synthesis and characterization of “clickable” 4-anilinoquinazoline kinase inhibitors

Perera, B. Gayani K., Maly, Dustin J.

Journal:

Molecular BioSystems

Year:

2008

Language:

english

File:

PDF, 662 KB

english, 2008

24

Conformation-Selective Inhibitors Reveal Differences in the Activation and Phosphate-Binding Loops of the Tyrosine Kinases Abl and Src

Hari, Sanjay B., Perera, B. Gayani K., Ranjitkar, Pratistha, Seeliger, Markus A., Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 5.37 MB

english, 2013

25

Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases

Hari, Sanjay B., Merritt, Ethan A., Maly, Dustin J.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

26

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors

Leonard, Stephen E., Register, A. C., Krishnamurty, Ratika, Brighty, Gabriel J., Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 3.18 MB

english, 2014

27

Bivalent inhibitors of protein kinases

Gower, Carrie M., Chang, Matthew E. K., Maly, Dustin J.

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

28

Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules

Gregersen, Kimberly A. D., Hill, Zachary B., Gadd, Jennifer C., Fujimoto, Bryant S., Maly, Dustin J., Chiu, Daniel T.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.18 MB

english, 2010

29

A Chemical Genetic Method for Generating Bivalent Inhibitors of Protein Kinases

Hill, Zachary B., Perera, B. Gayani K., Maly, Dustin J.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 1.21 MB

english, 2009

30

Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-carbamoylmethylcoumarin (ACC) Fluorophore

Maly, Dustin J., Leonetti, Francesco, Backes, Bradley J., Dauber, Deborah S., Harris, Jennifer L., Craik, Charles S., Ellman, Jonathan A.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 79 KB

english, 2002

31

Exploring the Intermembrane Space

Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2007

Language:

english

File:

PDF, 290 KB

english, 2007

32

Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors

Hill, Zachary B., Perera, B. Gayani K., Andrews, Simeon S., Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 4.59 MB

english, 2012

33

A Small Molecule-Regulated Guanine Nucleotide Exchange Factor

Goreshnik, Inna, Maly, Dustin J.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

34

Correction to “Affinity-Based Probes Based on Type II Kinase Inhibitors”

Ranjitkar, Pratistha, Perera, B. Gayani K., Swaney, Danielle L., Hari, Sanjay B., Larson, Eric T., Krishnamurty, Ratika, Merritt, Ethan A., Villén, Judit, Maly, Dustin J.

Journal:

Journal of the American Chemical Society

Year:

2013

File:

PDF, 118 KB

2013

35

Druggable sensors of the unfolded protein response

Maly, Dustin J, Papa, Feroz R

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.57 MB

english, 2014

36

SH2-Catalytic Domain Linker Heterogeneity Influences Allosteric Coupling across the SFK Family

Register, A. C., Leonard, Stephen E., Maly, Dustin J.

Journal:

Year:

2014

Language:

english

File:

PDF, 4.55 MB

english, 2014

37

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

KEYLOUN, KATELYN R., REID, MOLLY C., CHOI, RYAN, SONG, YIFAN, FOX, ANNA M. W., HILLESLAND, HEIDI K., ZHANG, ZHONGSHENG, VIDADALA, RAMASUBBARAO, MERRITT, ETHAN A., LAU, AUDREY O. T., MALY, DUSTIN J., F

Journal:

Year:

2014

Language:

english

File:

PDF, 269 KB

english, 2014

38

Chemical Genomic and Proteomic Methods for Determining Kinase Inhibitor Selectivity

Krishnamurty, Ratika, Maly, Dustin

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2007

Language:

english

File:

PDF, 393 KB

english, 2007

39

Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

Gower, Carrie M., Thomas, Jason R., Harrington, Edmund, Murphy, Jason, Chang, Matthew E. K., Cornella-Taracido, Ivan, Jain, Rishi K., Schirle, Markus, Maly, Dustin J.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.77 MB

english, 2015

40

Bumped kinase inhibitor prohibits egression in Babesia bovis

Pedroni, Monica J., Vidadala, Rama Subba Rao, Choi, Ryan, Keyloun, Katelyn R., Reid, Molly C., Murphy, Ryan C., Barrett, Lynn K., Van Voorhis, Wesley C., Maly, Dustin J., Ojo, Kayode K., Lau, Audrey O

Journal:

Veterinary Parasitology

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

41

In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

Winzer, Pablo, Müller, Joachim, Aguado-Martínez, Adriana, Rahman, Mahbubur, Balmer, Vreni, Manser, Vera, Ortega-Mora, Luis Miguel, Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Van Voorhis, Wesley C.,

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 2.53 MB

english, 2015

42

A novel protein kinase is essential in bloodstream Trypanosoma brucei

Jensen, Bryan C., Booster, Nick, Vidadala, Rama Subba Rao, Maly, Dustin J., Parsons, Marilyn

Journal:

International Journal for Parasitology

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

43

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents

Huang, Wenlin, Hulverson, Matthew A., Zhang, Zhongsheng, Choi, Ryan, Hart, Kevin J., Kennedy, Mark, Vidadala, Rama Subba Rao, Maly, Dustin J., Van Voorhis, Wesley C., Lindner, Scott E., Fan, Erkang, O

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

44

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

Bansal, Abhisheka, Ojo, Kayode K., Mu, Jianbing, Maly, Dustin J., Van Voorhis, Wesley C., Miller, Louis H.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

45

Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors

Golkowski, Martin, Vidadala, Rama Subba Rao, Lombard, Chloe K., Suh, Hyong Won, Maly, Dustin J., Ong, Shao-En

Journal:

Journal of Proteome Research

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

46

Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites

Müller, Joachim, Aguado-Martínez, Adriana, Balmer, Vreni, Maly, Dustin J., Fan, Erkang, Ortega-Mora, Luis-Miguel, Ojo, Kayode K., Van Voorhis, Wesley C., Hemphill, Andrew

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 2.70 MB

english, 2017

47

Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis

Müller, Joachim, Aguado-Martínez, Adriana, Ortega-Mora, Luis-Miguel, Moreno-Gonzalo, Javier, Ferre, Ignacio, Hulverson, Matthew A., Choi, Ryan, McCloskey, Molly C., Barrett, Lynn K., Maly, Dustin J.,

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2017

Language:

english

File:

PDF, 425 KB

english, 2017

48

Rheostatic control of Cas9-mediated DNA double strand break (DSB) generation and genome editing

Rose, John C., Stephany, Jason J., Wei, Cindy T., Fowler, Douglas M., Maly, Dustin J

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 785 KB

english, 2017

49

In vitro growth inhibition of Theileria equi by bumped kinase inhibitors

Gimenez, Fernanda, Hines, Siddra A., Evanoff, Ryan, Ojo, Kayode K., Van Voorhis, Wesley C., Maly, Dustin J., Vidadala, Rama S.R., Mealey, Robert H.

Journal:

Veterinary Parasitology

Year:

2018

Language:

english

File:

PDF, 440 KB

english, 2018

50

Toxoplasma calcium-dependent protein kinase 1 inhibitors: probing activity and resistance using cellular thermal shift assays

Scheele, Suzanne, Geiger, Jennifer A., DeRocher, Amy E., Choi, Ryan, Smith, Tess R., Hulverson, Matthew A., Vidadala, Rama Subba Rao, Barrett, Lynn K., Maly, Dustin J., Merritt, Ethan A., Ojo, Kayode

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2018

Language:

english

File:

PDF, 2.68 MB

english, 2018